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Sermorelin, ipamorelin, and CJC-1295 are three peptides that have gained popularity
in the fields of anti-aging medicine, sports performance enhancement, and
clinical research for their ability to stimulate growth hormone secretion in a controlled
manner. Each peptide has distinct structural features, mechanisms
of action, pharmacokinetics, therapeutic indications, potential side
effects, and legal status across different
jurisdictions.
Sermorelin is a synthetic analog of the naturally occurring growth hormone-releasing hormone (GHRH).
Its sequence mimics the first 44 amino acids of native
GHRH but includes modifications that increase its resistance to enzymatic degradation. By
binding to the GHRH receptor on pituitary somatotrophs, sermorelin triggers a cascade that releases endogenous growth hormone (GH) and
subsequently insulin-like growth factor-1 (IGF-1).
Because it does not directly stimulate GH receptors but rather provokes the
body’s own production of GH, its side-effect profile is generally milder than exogenous GH therapy.
Sermorelin is often prescribed for diagnosing GH deficiency in children and
adults; it can also be used off-label to address age-related declines in GH
levels.
Ipamorelin belongs to a class of peptides known as growth hormone secretagogues (GHS).
Its structure consists of a pentapeptide that selectively activates the ghrelin receptor (GHSR1a)
without stimulating cortisol or prolactin release. This selectivity is why ipamorelin is favored for use in research
and clinical protocols where minimal endocrine side effects are desired.
When administered, ipamorelin induces a rapid but short-lasting surge of GH
that peaks within 15–30 minutes and returns to baseline after
about an hour. It is frequently combined with other GHS agents or with CJC-1295 for synergistic growth hormone release.
CJC-1295 is a synthetic peptide that incorporates a linker sequence designed to extend its half-life by binding to albumin in the bloodstream.
The original version, often called „CJC-1295 without DAC” (drug affinity complex), has a relatively short half-life of 2–4 hours;
the newer „CJC-1295 with DAC” variant can last up to 8–10 days.
By mimicking GHRH and prolonging its activity, CJC-1295 sustains GH secretion over extended periods, leading
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water retention, and occasionally mild nausea.
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